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July 19 Is Munc13 a Switch for Neurotransmission? Structure of DNA has revolutionized biology because of its universality. How about the structure of protein? Many proteins have similar domains, but do they have similar functions? Many C2 domains have the Ca-dependent phospholipid binding property. However, here Rizo and his colleagure show that Munc13-1 C2A domain involves in protein interaction and this interaction might function as a switch for neurotransmission. It is relatively easy to know the amino acid sequence of a protein, but it is hard to predict its structure from its sequence, what's more, even we know the structure, the similar structures seem not to have similar function. Protein fulfill its function by interacting with other molecules, so the key question to understand protein function is to understand how it interacts with its targets; and the key to understand interactions is: domain? sequence? or complex environment? The regulated exocytosis might provide an excellent micro-environment to study how different proteins interact and collaborate to fulfill a function.
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