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August 05 An Evidence of Neural Circuits Contributing to Behavior Diacetyl is an attractive odorant to the worm C. elegans. Is this attraction behavior due to the odorant receptor or the olfactory neurons? Diacetyl is detected by the receptor ODR-10, which is expressed in the AWA neurons; while the repulsive odorant 2-nonanone is detected by receptor in the AWB neruons. When ODR-10 is transgenically expressed in the AWB neurons, the animal shows repulsive behavior to diacetyl, providing an evidence that neurons contribute to animal's behavior. Ref: Cell. 1997 Oct 17;91(2):161-9. July 06 Wisker Trimming and Cortex Spine Growth A central belief in neuroscience is that our behavior is the result of neural activity. If this is true, then a change of behavior will result in a change of neural activity, which can be a change either of the circuit structure or of the synaptic transmission. Here Holtmaat et al. demonstrated that wisker trimming (sensory experience change) enhances the spine formation and loss in the cortex (neural circuit structure change). This is the first step that relates functional circuitry to behavior, we still don't know the exact circuit structure and how this stucture contributes to specific behavior.
Circuits Model: whisker-to-barrel pathway. Background of cortical barrel.
Method: long-term in vivo two-photon imaging
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